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Methylprednisolone: Side effects, dosage, uses, and more
Methylprednisolone is a prescription medication used to reduce inflammation caused by many conditions. These include multiple sclerosis, rheumatoid arthritis, psoriasis, and ulcerative colitis. It is available as a generic drug and as the brand-name drug Medrol. Learn about side effects, warnings, dosage, and more.
Methylprednisolone, oral tablet
Medically reviewed by Femi Aremu, PharmD — Written by University of Illinois — Updated on August 31, 2021
Highlights for methylprednisolone
Methylprednisolone oral tablet is available as both a generic and brand-name drug. Brand name: Medrol.
This drug also comes as an injectable suspension and injectable solution. These forms are only given by a healthcare provider.
Methylprednisolone is used to reduce inflammation in many conditions. These include endocrine diseases, severe allergies, ulcerative colitis, and multiple sclerosis. It’s also used to treat rheumatic diseases, such as rheumatoid arthritis and osteoarthritis.
What is methylprednisolone?
Methylprednisolone oral tablet is a prescription drug that’s available as the brand-name drug Medrol. It’s also available as a generic drug.
Generic drugs usually cost less than the brand-name version. In some cases, the brand-name drug and the generic version may be available in different forms and strengths.
Methylprednisolone also comes as a suspension or solution. Those forms are given to you by a healthcare provider.
Why it’s used
This drug is used to treat many conditions. It helps to control inflammation and to modify your body’s immune response. The conditions it’s used to treat include:
endocrine disorders such as primary or secondary adrenocortical insufficiency
rheumatic disorders such as rheumatoid arthritis or psoriatic arthritis
collagen diseases such as lupus or systemic dermatomyositis
skin diseases such as psoriasis or Stevens-Johnson syndrome
severe allergies that haven’t been controlled with other treatment, such as seasonal or year-round allergies or allergic reactions to medications
eye problems such as swelling or ulcers (sores) in your eye
stomach or intestinal problems such as ulcerative colitis or Crohn’s disease
respiratory problems such as lung damage caused by beryllium poisoning, or by Loeffler’s syndrome that’s not controlled by other treatments
blood disorders such as low levels of platelets in adults, or lack of red blood cells in children
neoplastic diseases such as blood cancer or cancer in the lymphatic system in adults
multiple sclerosis flare-ups
infections, such as trichinosis with brain or heart problems
How it works
Methylprednisolone belongs to a class of drugs called glucocorticoids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Methylprednisolone works by decreasing inflammation and changing your body’s immune response. This reduces the inflammation caused by your condition.
Methylprednisolone side effects
Methylprednisolone oral tablet doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects of methylprednisolone can include:
headache nausea and vomiting weight gain
confusion, excitement, and restlessness
swelling of your ankles, feet, or hands
skin problems, such as acne, thin skin, and shiny skin
increased thirst infection high blood pressure muscle weakness depression
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Allergic reactions. Symptoms may include:
skin rash itching or hives
swelling of your face, lips, or tongue
Changes in your emotions and mood. Symptoms can include:
intense excitement or happiness
personality changes psychosis
Eye problems. Symptoms can include:
changes in your vision
eye pain bulging eyes
Trouble urinating or a change in how much you urinate
Diabetes. Symptoms can include:
urinating more often than normal
Pain in your hips, back, ribs, shoulders, arms, or legs
Infection. Symptoms can include:
fever sore throat sneezing coughing
Swelling of your ankles, feet, or hands
Wounds that won’t heal
Low potassium levels in your blood. Symptoms include:
irregular heart rhythm
Hormone changes. Symptoms can include:
loss of appetite lack of energy nausea vomiting headache fever
joint or muscle pain
skin irritation weight loss
low blood pressure (may make you feel dizzy or faint)Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Methylprednisolone may interact with other medications
Methylprednisolone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
How long does methylprednisolone tablets stay in your system?
Official answer: After taking a dose of a Methylprednisolone tablet it should be out of your system after approximately 13 to 20...
How long does methylprednisolone tablets stay in your system?
Medically reviewed by Drugs.com. Last updated on Feb 11, 2022.
After taking a dose of a Methylprednisolone tablet it should be out of your system after approximately 13 to 20 hours.
Methylprednisolone tablets have an elimination half-life of approximately 2.5 hours to 3.5 hours.
This is the time it takes for the drug levels in your plasma to reduce by half.
It takes approximately 5.5 times the elimination half-life for a medicine to be cleared from your body which is (5.5 x 2.5 hours) 13.75 hours to (5.5 x 3.5 hours) 19.25 hours.
Therefore the time for a methylprednisolone tablet to be removed from your body is approximately 13 to 20 hours.
Note: Depo-Medrol injection contains methylprednisolone acetate which has a longer half life and is a long acting injection.
However other factors to consider include:
1. How much and how often you have taken the drug.
2. Your metabolic rate – a slower metabolism will increase the time a drug remains in your system.
3. Your age and health – older age and poor health will generally increase the time the drug stays in your system.
4. Body mass – generally the bigger you are the longer a drug will remain in your system.
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How Long Does Methylprednisolone Stay In Your System?
Methylprednisolone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and aller
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How Long Does Methylprednisolone Stay In Your System?
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Methylprednisolone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.
Methylprednisolone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis.How should Methylprednisolone be used?
Methylprednisolone comes as a tablet to take by mouth. Your doctor will prescribe a dosing schedule that is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take methylprednisolone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Do not stop taking methylprednisolone without talking to your doctor. Stopping the drug abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss. If you take large doses for a long time, your doctor probably will decrease your dose gradually to allow your body to adjust before stopping the drug completely. Watch for these side effects if you are gradually decreasing your dose and after you stop taking the tablets. If these problems occur, call your doctor immediately. You may need to increase your dose of tablets temporarily or start taking them again.
Methylprednisolone also comes as an injection powder to be mixed with liquid to be injected intramuscularly (into a muscle) or intravenously (into a vein). It also comes as a suspension for injection to be injected intramuscularly, intra-articularly (into a joint), or intralesionally (into a lesion). Your personal dosing schedule will depend on your condition and on how you respond to treatment.
You may receive methylprednisolone injection in a hospital or medical facility, or you may be given the medication to use at home. If you will be using methylprednisolone injection at home, your healthcare provider will show you how to inject the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems using methylprednisolone injection.
Your doctor may change your dose of methylprednisolone injection during your treatment to be sure that you are always using the lowest dose that works for you. Your doctor may also need to change your dose if you experience unusual stress on your body such as surgery, illness, or infection. Tell your doctor if your symptoms improve or get worse or if you get sick or have any changes in your health during your treatment.How long does Methylprednisolone stay in your system?
There are several factors that come into play when estimating how long Methylprednisolone will stay in your system because every patient has physiology unique to them. Here are some major factors you should consider when trying to understand how long Methylprednisolone will stay in your body:• Age: Typically, the younger you are, the more efficient your body functions are. The more efficient your body functions, the faster Methylprednisolone will be removed from your system.
• Body height/weight/fat: Your specific prescribed Methylprednisolone dosage corresponds to your body height, weight, and fat. Usually, larger people will be given a higher dosage of Methylprednisolone. The higher the dose of Methylprednisolone you have been taking, the longer Methylprednisolone will take to be removed from your system.• Genetics: Genes predispose people to different metabolic functions, which is a key factor in how your body processes medications like Methylprednisolone. For this reason, your genetic makeup comes into play when estimating how long Methylprednisolone will remain in your system.
• Kidney and liver functions: The liver and kidneys eliminate everything you ingest, and Methylprednisolone is no exception. If your liver or kidneys are damaged, it will most likely take longer for your body to remove the Methylprednisolone from your system.• Metabolism: Your metabolism determines how quickly you process foods, liquids, and medications such as Methylprednisolone. If your metabolism is slow, it will take longer for your body to process and eliminate Methylprednisolone from its system than someone with a fast metabolism.• Usage frequency: The longer you have been taking Methylprednisolone, the longer it will remain in your system. For example, it will take longer for someone who has taken Methylprednisolone for several years to remove Methylprednisolone from the body than someone who has only been taking Methylprednisolone for a few months.