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    Taking naproxen with other medicines and herbal supplements

    NHS medicines information on possible interactions with naproxen and other medicines, herbal remedies and supplements.

    Taking naproxen with other medicines and herbal supplements

    Taking naproxen with other medicines and herbal supplements Cautions with other medicines

    There are some medicines that can affect the way naproxen works.

    Tell your doctor if you're taking:

    other anti-inflammatory medicines, such as aspirin or ibuprofen

    medicines that help to prevent blood clots, such as warfarin or rivaroxaban

    steroids, such as prednisolone

    medicines that make you pee more (diuretics), such as furosemide

    medicines used to treat heart problems and high blood pressure

    antidepressants, such as citalopram

    medicine used to treat rheumatoid arthritis, such as methotrexate

    Taking naproxen with other painkillers

    Do not take naproxen with ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs). But it's OK to take naproxen with paracetamol or co-codamol that you buy over the counter. This should just be for short periods of time.

    If you often need to take extra painkillers with naproxen or for more than a few days, talk to your doctor. Sometimes, taking different painkillers together is a good way to relieve pain, but there may be other treatments you can try.

    It's OK to take other painkillers with naproxen for longer if your doctor has given them to you on prescription and told you to take them together.

    If you're unsure, talk to your doctor.

    Mixing naproxen with herbal remedies and supplements

    There's not enough information to say that complementary medicines and herbal remedies are safe to take with naproxen. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

    Important: Medicine safety

    Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

    More in Naproxen

    Page last reviewed: 20 January 2022

    Next review due: 20 January 2025

    Source : www.nhs.uk

    Naproxen vs. ibuprofen: Similarities and differences

    Naproxen and ibuprofen are anti-inflammatory, pain relieving drugs. This article looks at their similarities and differences, including their uses, side effects, and drug interactions.

    What are the differences between naproxen and ibuprofen?

    Medically reviewed by Alan Carter, Pharm.D. — Written by Vincent A. Vidaurri, Pharm.D., BCOP on July 18, 2019

    We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Here’s our process.

    Naproxen and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs). They reduce pain, stiffness, swelling, and fever connected with inflammation.

    Naproxen (Aleve) and ibuprofen (Advil) are available at higher strengths as prescriptions and lower strengths when purchased over the counter.

    In this article, we provide an overview of the similarities and differences between naproxen and ibuprofen, including:

    how they work their uses how to take them side effects interactions costs

    use in pregnancy and breastfeeding

    How do they work?

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    Naproxen and ibuprofen may reduce pain, stiffness, and swelling.

    Naproxen and ibuprofen reduce inflammation by preventing an enzyme from making prostaglandins. Prostaglandins are a critical factor for inflammation.

    Inflammation is the body’s natural response to injury or infection. Doctors link chronic inflammation with various health conditions, including inflammatory bowel disease (IBD) and some forms of arthritis.

    Heat, redness, pain, and swelling are signs of inflammation. People may experience pain relief that can occur shortly after taking an NSAID, but it can take weeks for the inflammation to go away.

    When prostaglandins reach the brain, they can cause fever that naproxen and ibuprofen can also treat.

    By blocking the enzyme that produces prostaglandins, NSAIDs can impair platelet activity, hindering blood clots from forming.

    Differences in use

    Naproxen and ibuprofen can have different uses, some of which overlap.

    Experts approve naproxen for the following:

    ankylosing spondylitis

    bursitis gout attacks osteoarthritis

    body aches, minor muscle aches, and pains in bones and joints

    menstrual cramps and other menstrual pain

    rheumatoid arthritis


    People take ibuprofen for the following:

    fever headache migraine osteoarthritis pain menstrual cramps

    rheumatoid arthritis

    The American College of Rheumatology recommend NSAIDs for the initial management of osteoarthritis of the hands, hips, and knees but do not list one NSAID as more effective than another.

    However, some people should not take ibuprofen, such as those who are taking aspirin for heart protection.

    Although approving for rheumatoid arthritis use, the American College of Rheumatology’s 2015 recommendations do not list NSAIDs as a long term treatment option because of their side effects. People may use NSAIDs for a short period

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    early in rheumatoid arthritis, while other medications take effect.

    People can take an NSAID to treat menstrual cramps

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    , which can be effective in reducing pain, but researchers do not know whether one NSAID is better than another.

    How to take naproxen and ibuprofen

    Naproxen is available in two forms: Naproxen and naproxen sodium. The body absorbs naproxen sodium better than naproxen. Doses are in milligrams (mg) in the table below:

    Indication Naproxen Naproxen sodiumPain, menstrual pain, bursitis, and tendonitis No information provided 550 mg every 12 hours


    275 mg every 6–8 hours

    Ankylosing spondylitis, osteoarthritis, rheumatoid arthritis 250–500 mg twice daily 275–550 mg twice daily

    Acute gout 750 mg followed by 250 mg every 8 hours until the attack has subsided 825 mg followed by 275 mg every 8 hour

    Indication Ibuprofen

    Mild-to-moderate pain 400 mg every 4–6 hours

    Osteoarthritis, rheumatoid arthritis 400 mg, 600 mg, or 800 mg 3–4 times daily

    Menstrual pain 400 mg every 4 hours, as needed

    Minor side effects Share on Pinterest

    Side effects of naproxen and ibuprofen may include nausea and heartburn.

    The most common side effects of naproxen and ibuprofen are:

    heartburn constipation abdominal pain nausea headache dizziness drowsiness itching rash

    difficulty breathing

    fluid retention

    ringing in ears or tinnitus

    skin discoloration

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    Serious side effects

    Although available over the counter, naproxen and ibuprofen may not be safe for people with the following conditions:

    heart disease peptic ulcers stroke

    In 2015, the Food and Drug Administration (FDA)

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    strengthened an existing warning about non-aspirin NSAIDs, increasing the risk of heart attack or stroke.

    People who take prescription naproxen or ibuprofen may have increased risks for:

    stroke heart attack hemorrhagic death

    Source : www.medicalnewstoday.com

    Ibuprofen and naproxen Interactions

    A Major Drug Interaction exists between ibuprofen and naproxen. View detailed information regarding this drug interaction.

    Drug Interactions between ibuprofen and naproxen

    This report displays the potential drug interactions for the following 2 drugs:


    Edit list (add/remove drugs)



    Interactions between your drugs


    ibuprofen naproxen

    Applies to: ibuprofen and naproxen

    Using ibuprofen together with naproxen is generally not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation. Gastrointestinal perforation is a potentially fatal condition and medical emergency where a hole forms all the way through the stomach or intestine. You should take these medications with food to lessen the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. Your doctor may also be able to recommend medications to help protect the stomach and intestine if you are at high risk for developing serious gastrointestinal complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

    Switch to professional interaction data

    Drug and food interactions

    No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

    Therapeutic duplication warnings

    Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.


    Nonsteroidal anti-inflammatories

    Therapeutic duplication

    The recommended maximum number of medicines in the 'nonsteroidal anti-inflammatories' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'nonsteroidal anti-inflammatories' category:

    ibuprofen naproxen

    Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

    See Also

    Ibuprofen drug interactions

    Ibuprofen uses and side effects

    Naproxen drug interactions

    Naproxen uses and side effects

    Drug Interactions Checker

    Drug Interaction Classification

    These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.


    Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.


    Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.


    Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.


    No interaction information available.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

    Medical Disclaimer

    Source : www.drugs.com

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