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    CTE Center

    Boston University’s Chronic Traumatic Encephalopathy (CTE) Center conducts high-impact, innovative research on chronic traumatic encephalopathy and other long-term consequences of repetitive brain trauma in athletes and military personnel. The mission of the CTE Center is to conduct state-of-the-art research on CTE, including its neuropathology and pathogenesis, clinical presentation, genetics and other risk factors, biomarkers, methods of detection during life, and methods of prevention and treatment.

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    Source : www.bu.edu

    Chronic Traumatic Encephalopathy

    Chronic Traumatic Encephalopathy

    CTE is a neurodegenerative disease associated with repetitive brain trauma. Although the condition was described in the early 1900’s as dementia pugilistica and later in boxers as “punch drunk,” CTE has only recently received media attention and major research focus after it was discovered in professional football players. CTE has been diagnosed post-mortem in military service members exposed to blast injuries, and animal research has found that CTE neuropathology is directly associated with blast trauma.

    The CTE Center is an independent academic research center located at Boston University School of Medicine. The CTE Center collaborates with other institutions, partners, and academic researchers to expand our understanding of CTE.

    Source : www.bumc.bu.edu

    Boston University CTE Center and Brain Bank

    Boston University CTE Center and Brain Bank

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    The Boston University Medical Campus hosts the school's CTE Center and Alzheimer's Disease Center

    The Boston University CTE Center is an independently run medical research lab located at the Boston University School of Medicine. The Center focuses on research related to the long-term effects of brain trauma and degenerative brain diseases, specializing in the diagnosis and analysis of chronic traumatic encephalopathy (CTE). According to researchers at Boston University, CTE is a brain disease involving progressive neurological deterioration common in athletes, military personnel, and others who have a history of brain trauma.[1] The disease is primarily caused by repeated blows to the head, some of which result in concussions or sub-concussive symptoms.[2]

    Symptoms from CTE do not typically appear in a subject until many years after the initial injuries, and a conclusive diagnosis of the disease can only be achieved through autopsy.[2] In the years since its inception, the BU CTE Center and Brain Bank has devoted the majority of its time and effort into researching methods for diagnosing CTE in living subjects and developing potential treatments for the disease.[3]

    Although CTE remains mysterious and controversial, researchers have observed a link between the disease and the protein called tau, which slowly forms clumps in the brain that kill brain cells. This often results in subjects experiencing depression, anxiety, memory loss, headaches, and sleep disturbances.[1][4]

    Contents

    1 Formation

    2 Mission and Practices

    3 Notable People 3.1 Ann McKee 3.2 Chris Nowinski 3.3 Lisa McHale

    4 Notable Case Studies

    4.1 2009 Case Study

    4.2 2015 NFL Case Study

    4.3 2017 American Football Case Study

    4.4 Aaron Hernandez Autopsy

    5 Potential Applications of CTE Research

    6 See also 7 References

    Formation[edit]

    Boston University's CTE Center was formed as a part of the school's Alzheimer's Disease Center (BU ADC) which was established in 1996.[5] As the prominence of long-term brain injuries continued to grow in the early 2000s, the CTE Center collaborated with the United States Department of Veteran Affairs and the Concussion Legacy Foundation to form the VA-BU-CLF Brain Bank. This Brain Bank was officially formed in 2008, and acts as a subset of the Boston University School of Medicine. A brain bank is designed to act as a central resource for the collection and distribution of brain and brain tissue samples. Brain donors may donate their brains after death to aid in the understanding of neural diseases. Brain banks differ from other organ banks in that donated brains will only be used for research purposes, and will not be given to other individuals.[6]

    Dr. Ann McKee acts is the Director for the VA-BU-CLF Brain Bank and Boston University CTE Center, leading her team of researchers during group and individual case studies. McKee is aided in directing the Brain Bank by Dr. Chris Nowinski, CEO of the Concussion Legacy Foundation, and Lisa McHale, who acts as the Bank's director for family relations.[3] When the VA-BU-CLF Brain Bank formally opened in 2008, it became the first tissue repository in the world fully dedicated to the study of CTE.

    The Brain Bank continues to lead the field of CTE study, as it remains the largest brain tissue repository in the world that focuses on traumatic brain injuries and CTE. In partnership with the VA-BU-CLF Brain Bank, the Boston University CTE Center continues to be the most accomplished CTE research facility in the world, as the Center houses 70% of global CTE cases.[3]

    Mission and Practices[edit]

    The goal of the Boston University CTE Center is to collect and study post-mortem brains to better understand the long-term diseases associated with head trauma.[3] Specifically, the CTE Center focuses its research on the formation of neurodegenerative diseases, including Post-Concussion Syndrome and CTE. During case studies, researchers at the CTE Center perform high-impact tests and in-depth autopsies on post-mortem brains to further understand the neuropathology and clinical presentation of CTE. These tests examine the effects of concussions and sub-concussive blows on the brain, specifically as they relate to the development of CTE.[1][7][5]

    The Center's ultimate goal is to develop a test that would definitively diagnose CTE in a living subject.[8] In order to accomplish this, researchers at Boston University made it a priority to study as many post-mortem brains as possible, which led to the formation of the VA-BU-CLF Brain Bank. Currently, the Brain Bank contains over 600 brains, including 325 brains that have been diagnosed with CTE since the formation of the bank.[3]

    The directors of the VA-BU-CLF Brain Bank work with families of former athletes and veterans to create a well-rounded database that researchers can utilize during large CTE case studies. Employees of the Brain Bank collect tissue samples from the central nervous system (brain, eyes, and spinal cord) of deceased athletes, most notably American football professionals, and military veterans.[3] The Bank then stores these samples optimally to ensure proper care and treatment before, during, and after research testing. The Brain Bank directors will also share findings with family members and caregivers of the deceased.[5]

    Source : en.wikipedia.org

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