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A novel protodioscin

A novel protodioscin-enriched fenugreek seed extract (Trigonella foenum-graecum, family Fabaceae) improves free testosterone level and sperm profile in healthy volunteers

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A novel protodioscin-enriched fenugreek seed extract (Trigonella foenum-graecum, family Fabaceae) improves free testosterone level and sperm profile in healthy volunteers

Debasis Bagchi, Anand Swaroop, Anuj Maheshwari, Narsingh Verma, Kiran Tiwari, Manashi Bagchi, Harry G. Preuss, Pawan Kumar

Abstract

Background: A novel, patent-pending 20% protodioscin-enriched extract has been developed in our laboratories from fenugreek seeds (Furosap®). We assessed the efficacy of Furosap® in 50 male volunteers (age: 35-65 years) on free and total increased testosterone levels, sperm profile, mental alertness, cardiovascular health, mood, libido, and quality of life.Methods: Furosap® (500 mg/day/subject) was administered to the 50 male volunteers over a period of 12 weeks in a one-arm, open-labelled study, to determine the efficacy on free and total testosterone levels, sperm profile and sperm morphology, libido and erectile dysfunction, mood and mental alertness and broad spectrum safety parameters. Institution Review Board approval was obtained for this study and the study was registered at the clinicaltrials.gov (NCT02702882).Results: A statistically significant increase in free testosterone levels were observed in these volunteers following supplementation of Furosap®. Sperm morphology, sperm counts, mental alertness, mood, cardiovascular health, and libido performance were significantly improved. Extensive blood chemistry analyses revealed broad spectrum safety. No significant changes were observed in serum lipid function, cholesterol, triglyceride, HDL and LDL levels, and hemogram. Conclusions: Results confirmed that this protodioscin-enriched extract from fenugreek seeds (Furosap) is safe and efficacious in boosting serum free testosterone levels, healthy sperm profile, mental alertness, cardiovascular health, and overall performance in male volunteers.Keywords: Standardized fenugreek seed extract; Protodioscin; Testosterone booster; Sperm profile; Mood alleviation; Safety

Full Text: [Abstract] [Full Article]

DOI: 10.31989/ffhd.v7i4.326

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Copyright (c) 2017 Debasis Bagchi

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Effect of fenugreek extract supplement on testosterone levels in male: A meta

Different types of glycosides extract of fenugreek have shown androgenic and anabolic effect in male. The aim of the study was to evaluate the effect of fenugreek extract on total testosterone levels in male. Medline via PubMed, Scopus databases, Cochrane Library, Web of Science, and Google Scholar …

Review

. 2020 Jul;34(7):1550-1555.

doi: 10.1002/ptr.6627. Epub 2020 Feb 11.

Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials

Anahita Mansoori  1 , Seyedahmad Hosseini  1   2 , Marzie Zilaee  1   2 , Razie Hormoznejad  3 , Mojdeh Fathi  3

Affiliations

Affiliations

1 Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Nutrition Department, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 32048383

DOI: 10.1002/ptr.6627

Review

Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials

Anahita Mansoori et al. Phytother Res. 2020 Jul.

. 2020 Jul;34(7):1550-1555.

doi: 10.1002/ptr.6627. Epub 2020 Feb 11.

Authors

Anahita Mansoori  1 , Seyedahmad Hosseini  1   2 , Marzie Zilaee  1   2 , Razie Hormoznejad  3 , Mojdeh Fathi  3

Affiliations

1 Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Nutrition Department, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 32048383

DOI: 10.1002/ptr.6627

Abstract

Different types of glycosides extract of fenugreek have shown androgenic and anabolic effect in male. The aim of the study was to evaluate the effect of fenugreek extract on total testosterone levels in male. Medline via PubMed, Scopus databases, Cochrane Library, Web of Science, and Google Scholar were searched up to November 2018 for randomized clinical trials comparing intake of fenugreek extract with control group. Data on change in serum total testosterone were pooled using random-effects models. A total of four trials were included. Fenugreek extract has a significant effect on total serum testosterone. Results from clinical trials suggest that fenugreek extract supplement has an effect on serum total testosterone levels in male.

Keywords: fenugreek extract; total testosterone.

© 2020 John Wiley & Sons, Ltd.

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References

REFERENCES

Adamska, M., & Lutomski, J. (1971). C-Flavonoidglykoside In Den Samen Von Trigonella foenum-graecum. Planta Medica, 20(05), 224-229.

Al-Wabel, N., Mousa, H., Omer, O., & Abdel-Salam, A. (2008). Biological evaluation of aqueous herbal extracts and stirred yoghurt filtrate mixture against alloxan-induced oxidative stress and diabetes in rats. International Journal of Pharmacology, 4, 135-139.

Aswar, U., Bodhankar, S. L., Mohan, V., & Thakurdesai, P. A. (2010). Effect of furostanol glycosides from Trigonella foenum-graecum on the reproductive system of male albino rats. Phytotherapy Research, 24(10), 1482-1488. https://doi.org/10.1002/ptr.3129

Aydogan, U., Eroglu, A., Akbulut, H., Yildiz, Y., Gok, D. E., Sonmez, A., . . . Saglam, K. (2012). Evaluation of the isokinetic muscle strength, balance and anaerobic performance in patients with young male hypogonadism. Endocrine Journal, 59(4), 321-327.

Bahmani, M., Shirzad, H., Mirhosseini, M., Mesripour, A., & Rafieian-Kopaei, M. (2016). A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). Journal of evidence-based complementary & alternative medicine, 21(1), 53-62.

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Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study

To evaluate the efficacy and safety of the glycoside fraction of fenugreek (Trigonella foenum-graecum) seeds (Fenu-FG) on physiological parameters related to muscle anabolism, androgenic hormones, and body fat in healthy male subjects during an 8-week ...

J Sport Health Sci. 2016 Jun; 5(2): 176–182.

Published online 2015 Mar 7. doi: 10.1016/j.jshs.2014.09.005

PMCID: PMC6191980 PMID: 30356905

Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study

Sachin Wankhede,a,* Vishwaraman Mohan,b and Prasad Thakurdesaib

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This article has been corrected. See J Sport Health Sci. 2018 April; 7(2): 251.

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Abstract

Purpose

To evaluate the efficacy and safety of the glycoside fraction of fenugreek (Trigonella foenum-graecum) seeds (Fenu-FG) on physiological parameters related to muscle anabolism, androgenic hormones, and body fat in healthy male subjects during an 8-week resistance training program using a prospective, randomized, double-blind, placebo controlled design.

Methods

Sixty healthy male subjects were randomized to ingest capsules of Fenu-FG (1 capsule of 300 mg, twice per day) or the matching placebo at a 1:1 ratio. The subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The outcome measurements were recorded at recruitment (baseline) and at the end of the treatment (8 weeks). The efficacy outcome included serum testosterone (total and free) levels, muscle strength and repetitions to failure, metabolic markers for anabolic activity (serum creatinine and blood urea nitrogen), and % body fat. The standard safety measurements such as adverse events monitoring, vital signs, hematology, biochemistry, and urinalysis were performed.

Results

Fenu-FG supplementation demonstrated significant anabolic and androgenic activity as compared with the placebo. Fenu-FG treated subjects showed significant improvements in body fat without a reduction in muscle strength or repetitions to failure. The Fenu-FG supplementation was found to be safe and well-tolerated.

Conclusion

Fenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects.

Keywords: Anabolic, Androgenic, Fenugreek seeds, Glycosides, Randomized controlled study, Resistance training

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1. Introduction

Athletes use many nutritional supplements to improve their performance regardless of nutritional status.1 Therefore, interest in safer nutritional therapies and supplements for muscle building and performance enhancement is rising.

All performance enhancing supplements are regulated by the World Anti-Doping Code as defined by the World Anti-Doping Agency.2, 3, 4, 5 Many traditional herbal medicines are being investigated as safer alternatives for their nutritional benefits and performance enhancement. However, they need to be scientifically evaluated for their efficacy and safety in the relevant populations using standardized procedures such as randomized double-blind placebo controlled studies.6, 7

Fenugreek, Trigonella foenum-groecum L. (Fabaceae) seeds extract is a component of many nutritional dietary products that are recommended for athletes and exercising male subjects. Fenugreek seeds, a spice and food grain, has traditional history of medicinal use in the management of type 2 diabetes mellitus in Egypt, Southern Europe, India, Asia, and North Africa.8 Fenugreek seeds extract is certified as a GRAS (generally recognized as safe) item under clause §182.20 (essential oils, oleoresins and natural extractives including distillates) by the US Food and Drug Administration.

Traditionally, fenugreek seeds have been reported to be useful in hormonal regulation, in particular for male impotence and as a galactagogue in lactating mothers.9 In India, ground fenugreek seeds mixed with jaggery are recommended for females after childbirth for their anabolic effects to develop and strengthen muscles.10 Recent studies on fenugreek seeds extracts support their effectiveness in promoting lean body mass, and lowering cholesterol.11 Fenugreek extract is reported to enhance endurance capacity and the utilization of fatty acids as an energy source in male mice.12 One recent study on fenugreek extract reported fat reducing effects greater than placebo in young, healthy resistance-exercising males.13 These effects are purported to be mediated through an aromatase and 5α reductase inhibition, thereby increasing total testosterone levels by blocking its conversion to estrogen and dihydrotestosterone, respectively.13 Increased testosterone levels are known to increase muscle size and strength in men14 with downstream benefits on body weight, body fat, muscle size, strength, libido, energy, and mood.15, 16 Increased total testosterone levels could potentially affect serum free/bioavailable testosterone concentrations, resulting in escalated delivery and use by muscle cells to enhance protein synthesis, thus positively influencing strength and body fat. However, direct evidence for the androgenic effects of fenugreek seeds extract or its components in clinical practice is lacking.

Fenugreek seeds are rich in steroidal compounds like glycosides and saponins including diosgenin, yamogenin, gitogenin, tigogenin, and neotigogens. Diosgenin is an important precursor for the synthesis of a number of sex hormones.17 Diosgenin, a steroidal sapogenin, is reported to augment overall weight and muscle growth in rats.18 Moreover, diosgenin is reported to improve glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.19 We have previously shown the efficacy of the glycoside fraction of fenugreek seeds (Fenu-FG) on testosterone levels in immature castrated male rats.20 Recently, the excellent safety profile of sub-chronic (90-day) administration of Fenu-FG without any effects on body weight has been demonstrated in rats.21

Source : www.ncbi.nlm.nih.gov